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KMID : 0363620170380030030
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Journal of Korean Oriental Medicine
2017 Volume.38 No. 3 p.30 ~ p.42
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The Effect of Angelica gigas Nakai Extract and Bacillus Polyfermenticus KJS-2 on Atopic Dermatitis induced by DNCB in mice
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Ryu Deok-Hyun
Oh Sa-Rang
Jung Tae-Sung
Ryu Deok-Seon
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Abstract
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Objectives: The purpose of this study was to investigate the effects of Angelica gigas Nakai extract(AGNE) and Bacillus polyfermenticus KJS-2 (BP2) on atopic dermatitis (AD) induced by 2, 4-dinitrochlorobenzene (DNCB) in mice.
Methods: In the experiment, we divided mice into four groups: a control group, a DNCB group, an AGNE group, and an AGNE+BP2 group. Then we examined the changes in scratching frequency, clinical aspects on dorsum skin, immunoglobulin (IgE), cytokines (TNF-α, IL-6) and expression of COX-2.
Results: From the experiment, the scratching frequency was significantly dropped in AGNE group and AGNE+BP2 group. Clinical observations of dorsum skin, there were a severe keratotic lesion and drop of dead skin cell in DNCB group, but symptoms of AD were decreased 39.6% in AGNE group and 49.6% in AGNE+BP2 group during 3 weeks. IgE, TNF-α and IL-6 were decreased significantly in both AGNE and AGNE+BP2 group. Expression of COX-2 was also decreased significantly in both groups.
Conclusions: In conclusion, these data suggest that AGNE can decrease symptoms of AD and BP2 makes AGNE more effective. So AGNE can be useful herbal therapy for AD.
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KEYWORD
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Angelica gigas Nakai extract (AGNE), Bacillus polyfermenticus KJS-2 (BP2), 2, 4-dinitrochlorobenzene (DNCB), Atopic dermatitis (AD)
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